The relationship between genetic risk variants with brain structure and function in bipolar disorder: A systematic review of genetic-neuroimaging studies

Publikation: Bidrag til tidsskriftReviewForskningfagfællebedømt

Dokumenter

Licia P Pereira, Cristiano A Köhler, Rafael T de Sousa, Marco Solmi, Bárbara P de Freitas, Michele Fornaro, Rodrigo Machado-Vieira, Kamilla W Miskowiak, Eduard Vieta, Nicola Veronese, Brendon Stubbs, André F Carvalho

Genetic-neuroimaging paradigms could provide insights regarding the pathophysiology of bipolar disorder (BD). Nevertheless, findings have been inconsistent across studies. A systematic review of gene-imaging studies involving individuals with BD was conducted across electronic major databases from inception until January 9th, 2017. Forty-four studies met eligibility criteria (N=2122 BD participants). Twenty-six gene variants were investigated across candidate gene studies and 4 studies used a genome-wide association approach. Replicated evidence (i.e. in >2 studies) suggests that individuals with BD carrying the BDNF Val66Met risk allele could have reduced hippocampal volumes compared to non-carriers. This review underscores the potential of gene-neuroimaging paradigms to provide mechanistic insights for BD. However, this systematic review found a single replicated finding. Suggestions to improve the reproducibility of this emerging field are provided, including the adoption of a trans-diagnostic approach.

OriginalsprogEngelsk
TidsskriftNeuroscience & Biobehavioral Reviews
Vol/bind79
Sider (fra-til)87-109
ISSN0149-7634
DOI
StatusUdgivet - aug. 2017

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